setback

n. 顿挫,挫折,退步

Did he fall on a bad setback?

他是不是遭到了严重的挫折？

Ah well, I suppose there's nothing like an occasional setback to make you realize how lucky you really are.

唉，我看什么都不如偶尔受点挫折更能使你明白你是多么的幸运了。