disadvantage

n. 不利,不利条件,损害,损失

If you don't speak good English, you'll be at a big disadvantage when you try to get a job.

你要是英语讲得不好，找工作时就会处于非常不利的地位。

One of the main disadvantages of this system is that it uses very large amounts of fuel.

该系统的主要弱点之一是消耗大量燃料。