alienation

n. 疏远,离间,割让

Mental illness can create a sense of alienation from the real world.

精神病能产生一种与现实世界脱离的感觉。

The increasingly dull nature of many industrial jobs has led to the alienation of many workers.

许多工业工作越来越单调刻板，导致很多工人离心离德的倾向。