anguish

n. 苦闷,痛苦
v. 使...极苦闷,使...极痛苦

The child was badly hurt and was in anguish all the evening.

这个孩子受了重伤，整夜都在痛苦之中。

Physical disability causes mental anguish.

生理伤残会引起心理苦闷.